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KMID : 0360419700060010001
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Korean Journal of Pharmacology
1970 Volume.6 No. 1 p.1 ~ p.7
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The Effects of Diphenylhydantoin and Ouabain on ATPase Activity in Rat Erythrocyte Membrances
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Abstract
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The effects of ouabain and diphenylhydantoin on ATPase activity in rat erythrocyte membranes were studied and also influence of K on ATPase activity was studied.
The ATPase activity of rat erythrocyte membrane has been shown to consist of two components.
The first component requires the Mg but occurs in the absence of Na or K (Mg-ATPase) and is not inhibited by ouabain and stimulated by diphenylhydantoin.
The second component requires the presence of Mg and also Na or K (Na-K-Mg-ATPase). It is inhibited by ouabain and is stimulated by diphenylhydantoin in low Na concentration and inhibited in high Na concentration.
K inhibit Na-K-Mg-ATPase which is inhibited by ouabain.
Ouabain and diphenylhydantoin show reversed effect to Na-K-Mg-ATPase activity.
It suggest that the therapeutic effect of diphenylhydantoin on digitalis induced cardiac arrhythmia may be resulted from their effect on ion transport mechanism of cell membrance.
And the relevance of these findings to the action of ouabain and diphenylhydantoin on membrane transport mechanism is discussed.
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